Over the last few days, several users have reported problems with saved searches. Existing *.oss files no longer work and they cannot save new ones, as the Save and Save as menu items are grayed out.
This is caused by a security update, MS07-003 (http://www.microsoft.com/technet/security/bulletin/ms07-003.mspx) that was released Jan 9 2007.
For more information and the fix, see
http://support.microsoft.com/kb/925542/